![]() Methods Animal InterventionĪll animal protocols were approved by Institutional Animal Research Ethics Committee (approval no. Therefore, in the present study, we explored for the first time the putative effects of chronic energy drink consumption on blood-pressure in normotensive wild-type mice. However, the majority of previous studies have only tested short- to mid-term cardiovascular effects of acute energy drink consumption, and no studies to date have investigated long-term physiological effects. In a study with adult wild-type Wistar rats, an acute single oral gavaging of energy drink in combination with alcohol induced renal nephrotoxicity and hepatic hydropic and hyaline degenerations ( 4). The latter study also noted that of 24 subjects participated, 3 individuals had >50 ms QTc prolongation following the energy drink intake, imposing a potentially fatal event ( 3). Additionally, a study involving 24 patients with familial long QT syndrome showed a significant increase in QTc interval and an acute increase of systolic and diastolic blood pressure (DBP) following a singular challenge with consumption of an energy drink. Acute consumption of energy drink (~1,000 ml in 45 min) by young healthy individuals induced a significant prolongation of QTc interval and an elevation of systolic blood pressure (SBP) within 2 h of the beverage intake ( 2). A growing number of recent clinical randomized controlled trials and animal intervention studies report some profound detrimental effects of energy drinks on cardiometabolic conditions. Indeed, a recent survey study for university students in the US revealed that 51% of students regularly consume caffeinated energy drinks, particularly during the semester teaching period ( 1). Popularity of caffeinated energy drinks is markedly increasing, particularly amongst adolescents, and young adults. ![]() The study findings do not support consideration of energy drinks for BP management, but rather demonstrate no long-term amplification of BP in normotensive preclinical models. The estimated cumulative intake of caffeine, taurine, and vitamin B3 and B5 was significantly higher in the mice of Energy Drink and Sugar-free groups compared to the Control and Coke mice.Ĭonclusion: Collectively, the data suggest that the long-term chronic consumption of energy drinks may significantly lower the BP in normotensive mice through the actions of caffeine, taurine, and/or B-vitamins. The SBP, DBP, and MAP in Coke mice showed no significant changes. Similarly, Sugar-free group mice showed significant decrease of the SBP, DBP, and MAP by 10.85 ± 5.6, 18.7 ± 6.7, and 15.6 ± 6.1 mmHg, respectively. However, the Energy Drink significantly decreased the DBP and MAP by 18.8 ± 9.9 and 15.3 ± 9.8 mmHg, respectively. Results: After 13 weeks of intervention, the control mice showed a modest increase in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) by 7.1 ± 8.8, 5.8 ± 9.4, and 6.3 ± 9.1 mmHg, respectively. Research Methods and Procedures: Groups of mice were randomized to no treatment (water) (Control group), or to Mother™ provided as a decarbonated 30% (v/v) drinking solution (Energy Drink group), sugar-free Mother™ at 30% (Sugar-free group), Coca Cola™ at 30% (Coke group) for a total intervention period of 13 weeks. In this study, we investigated the effects of long-term energy drink ingestion on BP in C57BL/6J normotensive wild-type mice. However, few studies report the effect of chronic energy drink consumption on BP. Objective: Studies report that acute consumption of energy drinks transiently increases blood pressure (BP).
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